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- J Antibiot (Tokyo)1
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- ArticleNakanishi T, Tomita F, Furuya A.J Antibiot (Tokyo). 1977 Sep;30(9):736-42.The antibacterial activity of a new nucleoside antibiotic, 2'-amino-2'-deoxyguanosine (2AG), is reversed by guanosine and other purine nucleosides. 2AG is apparently taken up by E. coli by a mechanism different from that of guanosine; guanosine inhibits this uptake non-competitively. Insensitive E. coli strains and the resistant mutant obtained from the sensitive strain also took up 2AG.